Prolozone Therapy — How It Heals and Rejuvenates

By Dr. Benjamin Busch, DO, MBA

December 19, 2022

What is Prolozone Therapy?

Prolozone Therapy is a treatment that injects ozone into injured tissues to restart or reinvigorate the healing process. Prolozone comes from “proli,” which means to regenerate or rebuild, and “ozone” is an energized form of oxygen that causes a temporary “therapeutic stress” that pushes the body to respond with numerous healing antioxidant and biological reactions.

Your body already uses ozone and reactive peroxide molecules in daily immune responses and frequently handles reactive oxygen species (ROS) in the metabolic and detoxifying cascades within your cells. The therapeutic delivery of ozone into targeted tissue stimulates cellular reactions that have tremendous healing and rejuvenation effects.


Main benefits of Prolozone Therapy

ViveWell uses the natural biological benefits of Prolozone Therapy to treat 3 main categories of patient complaints: 

  1. Degenerative musculoskeletal conditions 
  2. Aesthetic skin conditions
  3. Fat loss

Musculoskeletal applications — joint, tendon, ligament and muscle

Looking for a therapeutic option to help relieve pain or injuries? It’s no secret that as we age things begin to change. Joint tissues already have low levels of oxygen and reduced blood flow, which limits the supply of nutrients and healing components. Low oxygen levels cause a buildup of lactic acid, which often results in pain, inflammation, and slow healing. Add injury and other illness to the equation and it’s no wonder millions of people suffer from degenerative joint conditions.  

Prolozone Therapy for musculoskeletal healing consists of two components: nutrients and ozone. The procedure adds nutrients and ozone involved in the regeneration process into the injured area. The ozone acts directly on the treated cells to improve metabolism, stimulate regenerative healing and increase blood flow, allowing the vitamins and minerals to spread further and deeper into joint spaces. It modulates the body’s inflammatory responses and speeds up the healing process. 


Video Testimonial

Hear from one ViveWell patient about her experience with joint pain relief via injection.

Oftentimes, patients choose to “stack” regenerative treatments by pretreating the area with prolozone and nutrients then adding additional healing elements like our PRP Therapy, peptides, and exosomes, which can be used together for exponential healing benefits.

Unlike steroid injections, which only reduce inflammation for a short period of time, prolozone treatment can assist in new tissue development and aid in reducing pain in the long term. In fact, research in Clinical Rheumatology concluded that while both corticosteroid injections and oxygen-ozone injections were both effective in reducing pain for patients with knee osteoarthritis, the effects of the oxygen-ozone injection lasted longer compared to the corticosteroid injection.

Overall, prolozone therapy:

  • reduces inflammation
  • relieves pain
  • enhances circulation
  • facilitates tissue repair

What about aesthetics? Prolozone helps skin, too.

The role of ozone in our bodies is truly beautiful. It’s a natural and elegant therapy for rejuvenation. If you’ve ever wished you could regenerate your skin to treat cosmetic flaws, ozone therapy might be what you need. It’s a simple, non-invasive technique to revive skin that’s dull or damaged. Thousands of practitioners worldwide are using ozone gas injections in their aesthetic practices to treat active acne and its scars, wrinkles, sagging skin, spider veins, scars, stretch marks and other signs of aging, refreshing their patient’s natural beauty.

The medical spa and aesthetics industry has long-used the principle of “therapeutic stress” when causing injury to dermal layers in hopes of stimulating regeneration of more youthful skin. Lasers, microneedling and emerging new techniques all rely on the body’s response to injury for the formation of new collagen and refreshed appearance of skin. Ozone is so strongly oxidative that it kills pathogens, increases circulation and decreases inflammation. It’s no wonder that ozone’s molecular therapy works to restore inner beauty.

Ozone for fat loss?

Dozens of research articles support the science behind this method, and when performed by skilled ViveWell providers, you’ll achieve impressive results with a series of minimally invasive treatments for trouble areas. Do you have a “muffin top” or other localized fat area you want to nip?  

ViveWell’s Medical Weight Loss program offers medication support, advanced metabolic and genetic testing to help you achieve lasting results. We’ll help you sculpt your body’s finishing touches with an inexpensive alternative to liposuction.

Cosmetologist measuring the patient's belly fat before a procedure

We get the best results with ozone for fat loss by treating the underlying cellular inflammation and insulin resistance causing the metabolic changes. Studies show people achieve optimal results for body contouring and aesthetic rejuvenation when used in conjunction with systemic ozone infusions that permeate the body’s tissues with healing messages.

Prolozone Therapy can be used to supplement conventional medicine for various conditions such as:

  • Acne
  • Cellulite
  • Cellulitis
  • Carpal tunnel syndrome
  • Chronic back pain
  • Chronic neck pain
  • Damaged vertebra or discs
  • Degenerated discs
  • Degenerated and arthritic ankles
  • Degenerated and arthritic hips
  • Degenerated and arthritic knees
  • Dental infections
  • Heel spurs
  • Neuromas
  • Non-union fractures
  • Painful scars
  • Pelvic disorders
  • Plantar fasciitis
  • Post-op pain
  • Rotator cuff injuries
  • Sciatica
  • Sinus infections
  • Skin rejuvenation
  • Spider veins
  • Sports injuries
  • Sprains and strains
  • Stretch marks
  • Tennis elbow
  • Wrinkles
Young mother with after birth stretch marks

How does the therapy work?

Prolozone Therapy at ViveWell

Treatment varies from person to person, depending on one’s ability to heal and the extent of the situation. Some people respond to injections after as few as 3 or 4 treatments, while others may need more. The injections are repeated every couple of weeks until you notice maximum improvement. More severe situations usually need more injections than others. 

Prolozone Therapy is a safe, natural and often permanent treatment method. No side effects have been reported when it is properly used. At ViveWell, we know each person’s situation is different, and we tailor your treatment to you.

Prolozone Therapy pricing – Requires consultation (from $150)

Prolozone Therapy (tendon, surgical / injury scars, wound)

  • Prolozone Injection (1 area) | from $150
  • Prolozone Injection 3-pack — 10% off | $540 (save $60)
  • Prolozone Injection 5-pack — 10% off | $675 (save $75)
  • Prolozone Injection 10-pack —15% off | $1,275 (save $225)

Prolozone Joint Treatments
(knee, ankle, shoulder, elbow, wrist)

Includes nutrient joint injection

Multi-joint injection savings must be purchased together.

  • One joint | $350
  • Additional joints | $300 per joint (save $50)

Prolozone Spine Treatments (Cervical, Thoracic, Lumbar, SacroIliac Joints)

Includes nutrient injection

  • Cervical (neck) | $450
  • Lumbar (low back) | $450
  • Thoracic (mid-back) | $450
  • SacroIliac joints $250

Prolozone Fat Loss Therapy

May require medical weight loss prior to intervention

Recommended 3-5 treatments per area

  • Stubborn Belly Fat | $300-$500 per session (depends on extent of treatment and number of injections)
  • Bra Bulge (both sides) | $300-$400 per session (depends on extent of treatment and estimated number of injections)
  • Double Chin | $250
  • Custom quotes available

Get better results by pairing Prolozone Fat Loss with UV-enhanced IV Ozone infusion | $250 per infusion

Prolozone Aesthetics (wrinkles and acne)

Recommended 3-5 treatments per area

  • Crows Feet (both sides) | $250
  • Forehead | $150
  • Lower face (both sides) | $250-$400 (final estimate discussed in consultation)
  • Stretch Marks | Custom quotes available
  • Quick Zit Fix (available to Vive Refresh Members only | $50 per treatment area (up to 3 per week)

Prolozone Peptide Injection Add-ons

Stack peptide treatments with Prolozone Therapy to enhance your results.

Consult with our team to determine which peptides will benefit your unique health most. 

  • Single Peptide add-on (1-2 areas) | $200
  • Double Peptide add-on (1-2 areas) | $350
  • Triple Peptide add-on (1-2 areas) | $500


  1. Shallenberger, F. Prolozone – regenerating joints and eliminating pain. Journal of Prolotherapy. 2011;3(2):630-638.
  2. Null G. Ozone: a wide-spectrum healer, Penthouse Mag. 1996; January 12.
  3. Hashemi M, Jalili P, Mennati S, Koosha A, Rohanifar R, Madadi F, Razavi SS, Taheri F. The effects of prolotherapy with hypertonic dextrose versus prolozone (intraarticular ozone) in patients with knee osteoarthritis. Anesth Pain Med. 2015 Oct;5(5): e27585
  4. Babaei-Ghazani A, Najarzadeh S, Mansoori K, Forogh B, Madani SP, Ebadi S, Fadavi HR, Eftekharsadat B. The effects of ultrasound-guided corticosteroid injection compared to oxygen-ozone (O 2–O 3) injection in patients with knee osteoarthritis: a randomized controlled trial. Clinical rheumatology. 2018 Sep;37(9):2517-27.
  5. Giurazza F, Guarnieri G, Murphy KJ, Muto M. Intradiscal O2O3: Rationale, Injection Technique, Short- and Long-term Outcomes for the Treatment of Low Back Pain Due to Disc Herniation. Can Assoc Radiol J. 2017 May;68(2):171-177. 
  6. Saber D, Saber NZ, Miller ET, Albrecht NV. Prolozone Injections/Ozone Injections.
  7. Alfaro S. Case Report: Treatment of Lateral Epicondylitis with PEMF. The Journal of Science and Medicine. 2019 Dec 1;1(1).
  8. Borges, F. dos S., Meyer, P. F., Jahara, R. S., Carreiro, E. de M., Antonuzzo, P. A., Picariello, F., & Palma, C. D. (2021, November 29). Fundamentals of the use of ozone therapy in the treatment of Aesthetic Disorders: A Review. Journal of Biosciences and Medicines. Retrieved December 6, 2022, from 
  9. Conti, G., et al. (2020) Proteomic and Ultrastructural Analysis of Cellulite—New Findings on an Old Topic. International Journal of Molecular Sciences, 21, 2077.
  10. Dunnill, C., et al. (2017) Reactive Oxygen Species (ROS) and Wound Healing: The Functional Role of ROS and Emerging ROS-Modulating Technologies for Augmentation of the Healing Process. International Wound Journal, 14, 89-96.
  11. Ashem, H.N. and Nagib, S.H. (2011) Ozone Therapy as an Adjunctive Modality for Weight Reduction in Grade II Adult Obese Subjects. Bulletin of Faculty of Pharmacy, Cairo University, 16, 71-77.
  12. Thakkar, V. and Thakkar, H. (2014) Ozone (O3): An Excellent Adjunctive Tool in Medical and Surgical Management of Patient. International Journal of Research in Medical Sciences, 2, 1257-1261. 
  13. Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-Endocrinology, 4(3), 308–319.

Integrative regenerative optimized healing

Located in beautiful Colorado, our clinic offers holistic customized treatment programs to improve and restore your health. For more information or to schedule your consultation, please contact us today. We’re here to answer any of your questions.

Disclaimer: All statements and opinions provided are for educational and informational purposes, not for medical diagnosis. As with all medical treatments and procedures, results may vary on an individual basis. ViveWell follows all FDA guidelines related to the treatments provided. You’re encouraged to consult with your primary care provider before undergoing any treatment programs offered by ViveWell. Some of our therapies are not FDA-approved. During your personal consultation, the benefits and risks of any recommended therapies will be reviewed with you.

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