Prolozone Therapy — How It Heals and Rejuvenates

By Dr. Benjamin Busch, DO, MBA

December 19, 2022

What is Prolozone Therapy?

Prolozone Therapy is a treatment that injects ozone into injured tissues to restart or reinvigorate the healing process. Prolozone comes from “proli,” which means to regenerate or rebuild, and “ozone” is an energized form of oxygen that causes a temporary “therapeutic stress” that pushes the body to respond with numerous healing antioxidant and biological reactions.

Your body already uses ozone and reactive peroxide molecules in daily immune responses and frequently handles reactive oxygen species (ROS) in the metabolic and detoxifying cascades within your cells. The therapeutic delivery of ozone into targeted tissue stimulates cellular reactions that have tremendous healing and rejuvenation effects.

Main benefits of Prolozone Therapy

ViveWell uses the natural biological benefits of Prolozone Therapy to treat 3 main categories of patient complaints:

Degenerative musculoskeletal conditions
Aesthetic skin conditions
Fat loss

Musculoskeletal applications — joint, tendon, ligament and muscle

Looking for a therapeutic option to help relieve pain or injuries? It’s no secret that as we age things begin to change. Joint tissues already have low levels of oxygen and reduced blood flow, which limits the supply of nutrients and healing components. Low oxygen levels cause a buildup of lactic acid, which often results in pain, inflammation, and slow healing. Add injury and other illness to the equation and it’s no wonder millions of people suffer from degenerative joint conditions.

Prolozone Therapy for musculoskeletal healing consists of two components: nutrients and ozone. The procedure adds nutrients and ozone involved in the regeneration process into the injured area. The ozone acts directly on the treated cells to improve metabolism, stimulate regenerative healing and increase blood flow, allowing the vitamins and minerals to spread further and deeper into joint spaces. It modulates the body’s inflammatory responses and speeds up the healing process.

Video Testimonial

Hear from one ViveWell patient about her experience with joint pain relief via injection.

Oftentimes, patients choose to “stack” regenerative treatments by pretreating the area with prolozone and nutrients then adding additional healing elements like our PRP Therapy, peptides, and exosomes, which can be used together for exponential healing benefits.

Unlike steroid injections, which only reduce inflammation for a short period of time, prolozone treatment can assist in new tissue development and aid in reducing pain in the long term. In fact, research in Clinical Rheumatology concluded that while both corticosteroid injections and oxygen-ozone injections were both effective in reducing pain for patients with knee osteoarthritis, the effects of the oxygen-ozone injection lasted longer compared to the corticosteroid injection.

Overall, prolozone therapy:

reduces inflammation

relieves pain
enhances circulation
facilitates tissue repair

“[Prolozone is] nothing short of remarkable in that damaged tissues can be regenerated and otherwise untreatable pain can be permanently cured.”

Frank Shallenberger, MD — Developer of the prolozone technique Tweet

What about aesthetics? Prolozone helps skin, too.

The role of ozone in our bodies is truly beautiful. It’s a natural and elegant therapy for rejuvenation. If you’ve ever wished you could regenerate your skin to treat cosmetic flaws, ozone therapy might be what you need. It’s a simple, non-invasive technique to revive skin that’s dull or damaged. Thousands of practitioners worldwide are using ozone gas injections in their aesthetic practices to treat active acne and its scars, wrinkles, sagging skin, spider veins, scars, stretch marks and other signs of aging, refreshing their patient’s natural beauty.

The medical spa and aesthetics industry has long-used the principle of “therapeutic stress” when causing injury to dermal layers in hopes of stimulating regeneration of more youthful skin. Lasers, microneedling and emerging new techniques all rely on the body’s response to injury for the formation of new collagen and refreshed appearance of skin. Ozone is so strongly oxidative that it kills pathogens, increases circulation and decreases inflammation. It’s no wonder that ozone’s molecular therapy works to restore inner beauty.

Ozone for fat loss?

Dozens of research articles support the science behind this method, and when performed by skilled ViveWell providers, you’ll achieve impressive results with a series of minimally invasive treatments for trouble areas. Do you have a “muffin top” or other localized fat area you want to nip?

ViveWell’s Medical Weight Loss program offers medication support, advanced metabolic and genetic testing to help you achieve lasting results. We’ll help you sculpt your body’s finishing touches with an inexpensive alternative to liposuction.

We get the best results with ozone for fat loss by treating the underlying cellular inflammation and insulin resistance causing the metabolic changes. Studies show people achieve optimal results for body contouring and aesthetic rejuvenation when used in conjunction with systemic ozone infusions that permeate the body’s tissues with healing messages.

Prolozone Therapy can be used to supplement conventional medicine for various conditions such as:

Acne
Cellulite
Cellulitis
Carpal tunnel syndrome
Chronic back pain
Chronic neck pain
Damaged vertebra or discs
Degenerated discs
Degenerated and arthritic ankles
Degenerated and arthritic hips
Degenerated and arthritic knees
Dental infections
Heel spurs
Neuromas
Non-union fractures

Painful scars
Pelvic disorders
Plantar fasciitis
Post-op pain
Rotator cuff injuries
Sciatica
Sinus infections
Skin rejuvenation
Spider veins
Sports injuries
Sprains and strains
Stretch marks
Tennis elbow
Wrinkles

How does the therapy work?

Prolozone Therapy is a unique form of ozone therapy that heals, regenerates and detoxifies all at the same time. Ozone is a highly charged, very energetic form of oxygen.

Prolozone Therapy is a natural regenerative injection treatment used to relieve joint pain, injuries and many aesthetic concerns. Ozone is a powerful oxidizer that can work with the body to deliver oxygen and nutrients to a localized area. While there is nothing we can do to stop time, new science and technologies can help us dramatically slow down the aging process, experience more health from our lives, and more joy in our days.

Learn more about Rejuvenation Medicine at ViveWell.

Prolozone Therapy at ViveWell

Treatment varies from person to person, depending on one’s ability to heal and the extent of the situation. Some people respond to injections after as few as 3 or 4 treatments, while others may need more. The injections are repeated every couple of weeks until you notice maximum improvement. More severe situations usually need more injections than others.

Prolozone Therapy is a safe, natural and often permanent treatment method. No side effects have been reported when it is properly used. At ViveWell, we know each person’s situation is different, and we tailor your treatment to you.

Prolozone Therapy pricing – Requires consultation (from $150)

Prolozone Therapy (tendon, surgical / injury scars, wound)

Prolozone Injection (1 area) | from $150
Prolozone Injection 3-pack — 10% off | $540 (save $60)
Prolozone Injection 5-pack — 10% off | $675 (save $75)
Prolozone Injection 10-pack —15% off | $1,275 (save $225)

Prolozone Joint Treatments
(knee, ankle, shoulder, elbow, wrist)

Includes nutrient joint injection

Multi-joint injection savings must be purchased together.

One joint | $350
Additional joints | $300 per joint (save $50)

Prolozone Spine Treatments (Cervical, Thoracic, Lumbar, SacroIliac Joints)

Includes nutrient injection

Cervical (neck) | $450
Lumbar (low back) | $450
Thoracic (mid-back) | $450
SacroIliac joints $250

Prolozone Fat Loss Therapy

May require medical weight loss prior to intervention

Recommended 3-5 treatments per area

Stubborn Belly Fat | $300-$500 per session (depends on extent of treatment and number of injections)
Bra Bulge (both sides) | $300-$400 per session (depends on extent of treatment and estimated number of injections)
Double Chin | $250
Custom quotes available

Get better results by pairing Prolozone Fat Loss with UV-enhanced IV Ozone infusion | $250 per infusion

Prolozone Aesthetics (wrinkles and acne)

Recommended 3-5 treatments per area

Crows Feet (both sides) | $250
Forehead | $150
Lower face (both sides) | $250-$400 (final estimate discussed in consultation)
Stretch Marks | Custom quotes available
Quick Zit Fix (available to Vive Refresh Members only | $50 per treatment area (up to 3 per week)

Prolozone Peptide Injection Add-ons

Stack peptide treatments with Prolozone Therapy to enhance your results.

Consult with our team to determine which peptides will benefit your unique health most.

Single Peptide add-on (1-2 areas) | $200
Double Peptide add-on (1-2 areas) | $350
Triple Peptide add-on (1-2 areas) | $500

BOOK YOUR PROLOZONE CONSULT

References

Shallenberger, F. Prolozone – regenerating joints and eliminating pain. Journal of Prolotherapy. 2011;3(2):630-638.
Null G. Ozone: a wide-spectrum healer, Penthouse Mag. 1996; January 12.
Hashemi M, Jalili P, Mennati S, Koosha A, Rohanifar R, Madadi F, Razavi SS, Taheri F. The effects of prolotherapy with hypertonic dextrose versus prolozone (intraarticular ozone) in patients with knee osteoarthritis. Anesth Pain Med. 2015 Oct;5(5): e27585
Babaei-Ghazani A, Najarzadeh S, Mansoori K, Forogh B, Madani SP, Ebadi S, Fadavi HR, Eftekharsadat B. The effects of ultrasound-guided corticosteroid injection compared to oxygen-ozone (O 2–O 3) injection in patients with knee osteoarthritis: a randomized controlled trial. Clinical rheumatology. 2018 Sep;37(9):2517-27.
Giurazza F, Guarnieri G, Murphy KJ, Muto M. Intradiscal O2O3: Rationale, Injection Technique, Short- and Long-term Outcomes for the Treatment of Low Back Pain Due to Disc Herniation. Can Assoc Radiol J. 2017 May;68(2):171-177.
Saber D, Saber NZ, Miller ET, Albrecht NV. Prolozone Injections/Ozone Injections.
Alfaro S. Case Report: Treatment of Lateral Epicondylitis with PEMF. The Journal of Science and Medicine. 2019 Dec 1;1(1).
Borges, F. dos S., Meyer, P. F., Jahara, R. S., Carreiro, E. de M., Antonuzzo, P. A., Picariello, F., & Palma, C. D. (2021, November 29). Fundamentals of the use of ozone therapy in the treatment of Aesthetic Disorders: A Review. Journal of Biosciences and Medicines. Retrieved December 6, 2022, from https://www.scirp.org/journal/paperinformation.aspx?paperid=113644
Conti, G., et al. (2020) Proteomic and Ultrastructural Analysis of Cellulite—New Findings on an Old Topic. International Journal of Molecular Sciences, 21, 2077. https://doi.org/10.3390/ijms21062077
Dunnill, C., et al. (2017) Reactive Oxygen Species (ROS) and Wound Healing: The Functional Role of ROS and Emerging ROS-Modulating Technologies for Augmentation of the Healing Process. International Wound Journal, 14, 89-96. https://doi.org/10.1111/iwj.12557
Ashem, H.N. and Nagib, S.H. (2011) Ozone Therapy as an Adjunctive Modality for Weight Reduction in Grade II Adult Obese Subjects. Bulletin of Faculty of Pharmacy, Cairo University, 16, 71-77.
Thakkar, V. and Thakkar, H. (2014) Ozone (O3): An Excellent Adjunctive Tool in Medical and Surgical Management of Patient. International Journal of Research in Medical Sciences, 2, 1257-1261.
Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-Endocrinology, 4(3), 308–319. https://doi.org/10.5455/2320-6012.ijrms20141104

Integrative regenerative optimized healing

Located in beautiful Colorado, our clinic offers holistic customized treatment programs to improve and restore your health. For more information or to schedule your consultation, please contact us today. We’re here to answer any of your questions.

Disclaimer: All statements and opinions provided are for educational and informational purposes, not for medical diagnosis. As with all medical treatments and procedures, results may vary on an individual basis. ViveWell follows all FDA guidelines related to the treatments provided. You’re encouraged to consult with your primary care provider before undergoing any treatment programs offered by ViveWell. Some of our therapies are not FDA-approved. During your personal consultation, the benefits and risks of any recommended therapies will be reviewed with you.